Which condition is characterized by a wrinkled appearance in the mouth?

The condition characterized by a wrinkled appearance in the mouth is indeed Snuff Keratosis. This condition arises primarily in individuals who use smokeless tobacco products, such as snuff. The main risk factor is the continuous irritation and trauma to the oral mucosa, which leads to changes in the epithelial tissue. Over time, this results in a distinct wrinkled or corrugated appearance of the affected areas in the mouth.

The changes may also be accompanied by a whitish appearance due to keratinization, but the hallmark of Snuff Keratosis is that characteristic wrinkled texture. This alteration in the oral cavity is a response to the harsh chemicals and physical irritation caused by the tobacco product.

The other conditions listed present with different symptoms and characteristics, such as leukoplakia presenting as white patches, oral thrush reflecting fungal infections often leading to a white coating on the tongue and mucosa, and periodontal disease primarily affecting the gums and associated structures rather than causing a wrinkled appearance. Thus, Snuff Keratosis is specifically recognized for its unique wrinkled presentation in the mouth.